Like ibuprofen, it’s best to start taking tramadol at the first signs of pain since waiting too long may cause it to be ineffective. To properly use tramadol, take the medication orally as directed by the packaging or your doctor’s instructions. Once you start taking tramadol every day, it can be difficult to stop it. If I missed more than one day, I would get D and a lot of stomach/intestinal pain plus other fun symptoms. Some people are more sensitive to it than others. I am taking Tramadol that expired 2 years ago to control my pain. It has been stored for over 3 years at room temperature. It is relieving my pain beautifully without any side effects. I am uninsured and cannot afford medications nor a doctor's bill so I am very grateful that I kept the expired Tramadol for without it I would not able to function enough to write this testimony. If you are not. Hey there. If you're prescribed Tramadol for pain and aren't getting relief, talk to your doctor. But if you're taking Tram to get high, that's obviously something else. I am also taking tylenol 650 mg along with the Tramadol, thinking I won't become addicted. I still have never felt any relief for the pain in my ankle (broken 3 years ago). I started taking 400mgs of ibuprofen after 3 hrs due to pain breakthrough with the Tramadol. Helped for a few weeks. I then started taking Tramadol and 400mgs ibuprofen at the same time. This combo works the best but this is no way to live. Don’t stop taking the drug, especially if you have taken it for weeks or months. Your doctor will adjust your dosage to slowly taper you off the drug. This helps prevent withdrawal. Tell your. Tramadol oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. You may decide to stop taking tramadol on your own, but make sure to let your doctor know that you intend to stop. Your physician will be able to help you gradually reduce tramadol use in order to minimize withdrawal symptoms. How to use Tramadol HCL. Read the Medication Guide provided by your pharmacist before you start taking tramadol and each time you get a refill. If you have any questions, ask your doctor or.